Tripeptide-29 is a cosmetic peptide widely utilized within daytime serums, post-sun care products, and barrier reconstruction following various medical aesthetic procedures.
Derived from the cleavage of Gly-Pro-Hyp, this minimal fragment represents the highest repetition found in the α1 chain of Type I collagen; maintaining the triple-helix conformation of said collagen is its primary critical function.
Thermodynamic studies have shown this tripeptide fragment to be structurally stable, an intramolecular hydrogen bond network (pyrrolidine ring to hydroxyl group being the key) significantly extending its in-vivo half-life.
The minimal fragment design itself avoids the associated side effects of longer peptide chains, a more hydrophobic structure enhancing skin permeability.
序列
Gly-Pro-Hyp
化学文摘社编号
2239-67-0
分子式
C12H19N3O5
分子量
285.30
Tripeptide-29 Related Research
1.Key Biological Activities
Full efficacy of the parent collagen α1 chain is retained; intact signaling is mimicked, activating fibroblast specific pathways towards collagen synthesis – production of new collagen being the end result, wrinkle reduction being one of the more measurable outcomes.
Inhibiting overexpression of matrix metalloproteinases is another positive effect, destructive enzyme synthesis is suppressed for healthy collagen survival.
Chain oxidation reactions are interrupted, chemical sunscreen level primary photodamage protection is delivered (barrier and hydration functions being strengthened).
Active regulation of all of these molecular level events constructs a true skin repair and anti-aging pathway.
2.Collagen Regeneration
High affinity binding to TβR-III (Transforming growth factor beta receptor III) is what sets Tripeptide-29 apart; degradation signals are effectively simulated.
New, structurally sound Type I and III collagen are synthesized as a direct result.
Firmer, more youthful dermis is the observed outcome.
3.Collagen Degradation Inhibition
Tripeptide-29 suppresses the excessive production of matrix metalloproteinases (MMPs) within skin cells.
Downregulation of specific intracellular signaling pathways and the subsequent expression of various inflammatory factors are key mechanisms in this process.
Genetically speaking, MMP expression is suppressed; the loss of previously established collagen networks is slowed.
A stable environment for both synthesis and maintenance of new collagen is provided.
Prolonging the youthful appearance of skin is a primary outcome of this action; skin firmness is maintained through this continuous process.
4.Photoprotection and Brightening Effects
Research shows Tripeptide-29 forms a dense triple-helix conformation on the outer membrane of melanosomes.
Tyrosinase is kept from entering the cell interior, direct melanin production being thus inhibited.
UV damage to the skin is reduced, evenness of skin tone following prolonged exposure occurs.
Acute sunburn related redness, swelling and burning sensations are significantly alleviated.
Chronic photoaging signs do not worsen as a result.
Compatible with all forms of commercial sunscreen, comprehensive photoprotection is achievable.
COA
高效液相色谱法
MS
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