Semelo le Mathata
Ho tloha ha peptide ea pele ea gly-gly e entsoe ka hare 1901, peptide synthesis e fetile ho feta 100 lilemo tsa tsoelopele, le joalo ka monkakarolo oa bohlokoa mesebetsing ea bophelo, e bontšitse bokhoni bo boholo mafapheng a ho sibolla le nts'etsopele ea lithethefatsi, lintho tse phelang, le litlolo. Mekhoa ea setso ea ho kopanya peptide ha e sebetse hantle, theko e boima, le ho silafatsa tikoloho, tse thibelang tshebediso ya tsona e pharalletseng ka botebo. Tsoelo-pele ea katleho, theknoloji ea peptide e tala le ea moruo e fetohile phephetso e potlakileng. Mona, e thehiloeng motheong oa khopolo-taba oa lipatlisiso tsa saense, re sebelisa khopolo ho itlhakisa le ho hlokomela ka katleho ts'ebeliso ea theknoloji ea catalytic peptide synthesis tlhahisong ea 'nete.
Khatelo-pele ea theknoloji
Molek'hule o monyane oa li-bifunctional organic: Ho sebelisa thiourea-tertiary amine synergistic catalysis, re ile ra atleha ho qoba ho kenya letsoho ha tšepe 'me ra hlokomela theknoloji e tala ea ho kopanya ntle le tšepe.
- Mokhoa o ikhethileng oa ho arabela: tertiary amine e hula haedrojene ho ntlafatsa nucleophilicity ea sehlopha sa amino, mme sebopeho se thata sa thiourea se hlokomela mosebetsi oa ho hapa sehlopha sa amino, ka hona ho hlokomela catalysis e tsitsitseng.
- E ntlafalitse haholo ts'ebetso ea ho kopanya: bokhoni ba ho kopanya mohato o le mong tlas'a maemo a mokelikeli o khutsufalitsoeng ho 5 metsotso, mme katleho ea ho kopanya e phahame joalo ka 99%.
- Theknoloji ea k'hemistri e tala: Sistimi ea metsi / ionic e nka sebaka sa DMF ho fokotsa tlhahiso ea litšila tse phelang, mme sehlahisoa ke metsi feela, bonolo kamora ho sebetsa, le e loketseng bakeng sa ho tsoela pele phallo reactor, ho hlokomela motsoako o tsoelang pele oa peptide ka tekanyo ea lik'hilograma.
Qetello
Theknoloji ea thiourea-tertiary amine co-catalyzed peptide synthesis e ka haha lilaeborari tsa peptide ka potlako bakeng sa tlhahlobo e phahameng., e khutsufatsa haholo R&D potoloho ea anticancer le antiviral lithethefatsi, tšehetsa tlhahiso e kholo ea li-peptide tse rarahaneng, le ho khothaletsa litlhare tse ngata tsa peptide ho kena lipatlisisong tsa bongaka. E fokotsa tšebeliso ea li-reagents le li-solvents, 'me ka katleho e theola litšenyehelo tsa peptide synthesis, 'me e ka lemoha ka potlako motsoako o moholo oa li-peptide.
